Outside the story, the player is able to complete side missions to unlock additional content and collectible items.

Spider-Man can freely move around New York City, interacting with characters, undertaking missions, and unlocking new gadgets and suits by progressing through the main story or completing tasks. Gameplay is presented from the third-person perspective with a primary focus on Spider-Man's traversal and combat abilities. When Mister Negative threatens to release a deadly virus, Spider-Man must confront him and protect the city while dealing with the personal problems of his civilian persona, Peter Parker. In the main story, the super-human crime lord Mister Negative orchestrates a plot to seize control of New York City's criminal underworld. Based on the Marvel Comics character Spider-Man, it tells an original narrative that is inspired by the long-running comic book mythology, while also drawing from various adaptations in other media. Marvel's Spider-Man is a 2018 action-adventure game developed by Insomniac Games and published by Sony Interactive Entertainment.

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